MONASCUS

Manfaat Utama :


1. Merendahkan lipid darah dengan cepat dan
berkesan.


2. Mencegah daripada hiperlipidemia(kehadiran
paras lipid yang tinggi di dalam darah).


3. Berkesan mencegah dan melegakan penyakit
jantung koronari, arteriosklerosis dan strok.





AN INTRODUCTION OF MONASCUS PURPUREUS


Monascus purperus is a red mold species which may be cultivated on starch containing substrates. The solid state fermentation of rice by Monascus has a long tradition in East Asian countries which dates back at least to the first century A.D. The fermentation is obtained as scarlet to purple red grains which have the original rice grain structure well preserved.



This fungus is most important because of its use, in the form of red yeast rice. Red Yeast rice, known as “Hong Qu” in China, is a traditional Chinese medicine that is made from rice. The material has been used in China as a dietary supplement as well as for curing diseases for about more than 1000 years.














Hawthorn



Tasly Monascus is totally made from natural - rice. The special characteristics of this product include unique producing techniques, standardized manufacturing procedure, and strict quality control and clearly defined main active ingredients. Tasly Monascus contains naturally - occurring substances called Monascus purperus (monacolins). Monacolins, particularly called lovastatin, will be converted into the body to a substance that inhibits HMG-CoA reductase. HMG-CoA reductase is an enzyme that triggers cholesterol production. Tasly Monascus has positive effect of reducing the level of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) as well as increasing the level of high - density lipoprotein cholesterol (HDL-C). Besides lovastatin, the active ingredients of Tasly Monascus are linoleic acid, ergosterin, saponin, flavones, unsaturated fatty acids and 18 amino acids, which can significantly decreases the cholesterol level.



Blood Lipids and Lipid Transport

Lipids are insoluble (does not dissolve) in water but are soluble (dissolves) in alcohol and other solvents. When dietary fats are digested and absorbed into the small intestine, they eventually re-form into triglycerides, which are then packaged into lipoproteins.Dietary fats, including cholesterol, are absorbed from the small intestines and transported into the liver by lipoproteins called chylomicrons.


Chylomicrons are large droplets of lipids with a thin shell of phospholipids, cholesterol and protein. Once chylomicrons enter the bloodstream, an enzyme called lipoprotein lipase breaks down the triglycerides into fatty acid and glycerol. After a 12- to 14-hour fast, chylomicrons are absent from the bloodstream. Thus, individuals who are having a lipid profile done should fast overnight to ensure that chylomicrons have been cleared.


The liver removes the chylomicron fragments and the cholesterol is repackaged for transport in the blood in very low-density lipoproteins (VLDLs), which eventually turn into low-density lipoproteins (LDL). LDL cholesterol (LDL - C) - the "bad cholesterol"- consists mainly of cholesterol. Most LDL particles are absorbed from the bloodstream by receptor cells in the liver.

Cholesterol is then transported throughout the cells. Diets high in saturated fats and cholesterol decrease the uptake of LDL particles by the liver. LDL particles are also removed from the bloodstream by scavenger cells, or macrophages, which are white blood cells that bury themselves in blood vessels such as arteries. Scavenger cells prevent cholesterol from reentering the bloodstream, but they deposit the cholesterol in the inner walls of blood vessels, eventually leading to the development of plaque.


High-density lipoproteins (HDLs) are a separate group of lipoproteins that contain more protein and less cholesterol than LDL.. HDL cholesterol (HDL - C) is also called "good cholesterol." HDL is produced primarily in the liver and intestine, and it travels in the bloodstream, picks up cholesterol, and gives the cholesterol to other lipoproteins for transport back to the liver.


What diseases will be caused by high blood lipid level (hyperlipidemia)?

Lipid disorders occurs when you have excess fatty substances in your blood. These substances include cholesterol and triglycerides. Having a lipid disorder makes you more likely to develop atherosclerosis and heart disease.

High cholesterol and other lipid disorders can be inherited (passed down through families) or associated with:
• Fatty diets.
• Disease such as diabetes, hypothyroidism, cushing syndrome and kidney failure.
• Certain medications, including birth control pills, estrogen, corticosteroids, certain diuretics beta-blockers.
• Lifestyle factors, including inactivity and regular, excessive alcohol use. Lovastatin naturally contended in Tasly Monascus can inhibits HMG-CoA reductase so as to prevent synthesis of endogenous cholesterol. Endogenous cholesterol is cholesterol that made inside the body and is not in the diet. Meanwhile, exogenous cholesterol is cholesterol that enters the body from diets.



Mechanism of lowering exogenous cholesterol

Ergosterin will compete with cholesterol to disturb absorption of cholesterol into body. It is because; ergosterin chemical structure’s is relatively similar with cholesterol.

Mechanism of lowering triglycerides

Linoleic acid is very beneficial for people with hypertriglyceridemia (denotes high blood levels of triglycerides). Linoleic Acid is a polyunsaturated fatty acid that is part of the Omega 6 fatty acids family. It is a precursor for a hormone like substance prostaglandins. Prostaglandins are substances found in the body's cells. Linoleic acid is an essential fatty acid the body cannot produce itself so it must be included in the diet.


NOTE: The content stated here are mostly using scientific terms for Amedical explaination approach. Please do not hesitate to contact us for further details and explaination.


3 Major efficacies of Tasly Monascus:

1. Lower the blood lipid rapidly and effectively.
2. Prevent hyperlipidemia (presence of high level of lipid in the blood).
3. Effectively prevent and relieve coronary heart disease, atherosclerosis and stroke.